base pair

1 of 2

noun

plural base pairs
: one of the pairs of nucleotide bases on complementary strands of nucleic acid that consist of a purine on one strand joined to a pyrimidine on the other strand by hydrogen bonds holding together the two strands much like the rungs of a ladder and that include adenine linked to thymine in DNA or to uracil in RNA and guanine linked to cytosine in both DNA and RNA

base pair

2 of 2

verb

base paired or base-paired; base pairing or base-pairing; base pairs or base-pairs

intransitive verb

: to participate in formation of a base pair
adenine base-pairs with thymine

Examples of base pair in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Noun
The team measured the length of each human DNA fragment in the samples by calculating the number of base pairs along each strand. Katie Hunt, CNN Money, 7 Nov. 2025 Called AlphaGenome, the model takes in sequences of up to one million DNA letters, also known as base pairs, and predicts how mutations in those stretches affect gene expression. Tanya Lewis, Scientific American, 28 Jan. 2026
Verb
As a rule of thumb, the shorter the sequence or read of base pairs, the older the DNA, Meyer-Kaiser said. Katie Hunt, CNN Money, 7 Nov. 2025 Each species’ genome contains billions of base pairs, and even small mutations (a few hundred or thousand changes) create new biological identities. Big Think, 29 Oct. 2025 See All Example Sentences for base pair

Word History

First Known Use

Noun

1955, in the meaning defined above

Verb

1959, in the meaning defined above

Time Traveler
The first known use of base pair was in 1955

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Cite this Entry

“Base pair.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/base%20pair. Accessed 7 Jul. 2026.

Medical Definition

: one of the pairs of nucleotide bases on complementary strands of nucleic acid that consist of a purine on one strand joined to a pyrimidine on the other strand by hydrogen bonds holding together the two strands much like the rungs of a ladder and that include adenine linked to thymine in DNA or to uracil in RNA and guanine linked to cytosine in both DNA and RNA

base pair

2 of 2 intransitive verb
variants or base-pair
: to participate in formation of a base pair
adenine base pairs with thymine
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